Researchers found that the main gene that causes Rett syndrome, MeCP2, controls the differentiation pattern of neural stem cells through the microRNA miR-199a. Dysfunction in MeCP2 or miR-199a cause neural stem cells to produce more astrocytes than neurons. Furthermore, the researchers found that miR-199a mediates the production of Smad1, a downstream transcription factor of bone morphogenetic protein (BMP) signaling.
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