Brain metastases can only develop if cancer cells exit the capillaries and enter into the brain tissue. To facilitate this step, cancer cells influence blood clotting, as scientists have now been able to show in mice. The cancer cells actively promote the formation of clots, which helps them to arrest in the brain capillaries and then penetrate through the vessel wall. Drugs that inhibit thrombin were able to reduce the number of brain metastases.
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